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short transient receptor potential channel 5 (TrpC5, Htrp-5, Htrp5, TRP5)
Function:
1) forms a receptor-activated selective vs non-selective Ca+2 permeant cation channel
2) probably regulated by phosphatidylinositol 2nd messenger system activated by receptor tyrosine kinases or G-protein coupled receptors
3) may be activated by intracellular Ca+2 store depletion
4) interacts with NHERF
Structure:
- belongs to the transient receptor family, STrpC subfamily
- contains 2 ANK repeats
Compartment: membrane
Expression: expressed in brain, higher levels in fetal brain
General
Ca+2 channel
transmembrane 6 protein
Properties
SIZE: MW = 111 kD
entity length = 973 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-330}
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 69-98
ankyrin repeat
NAME: ankyrin repeat
SITE: 141-170
transmembrane domain {331-351}
exoplasmic loop {352-398}
transmembrane domain {399-419}
cytoplasmic loop {420-437}
transmembrane domain {438-458}
exoplasmic loop {459-470}
MOTIF: N-glycosylation site {N461}
transmembrane domain {471-491}
cytoplasmic loop {492-512}
transmembrane domain {513-533}
exoplasmic loop {534-603}
transmembrane domain {604-624}
cytoplasmic domain {625-973}
MOTIF: binding site
SITE: 971-973
FOR-BINDING-OF: Na+/H+ exchange regulatory cofactor NHE-RF1
FOR-BINDING-VIA: PDZ domain
ION-PERMEABILITY: Ca+2
Database Correlations
OMIM 300334
UniProt Q9UL62
PFAM correlations
References
UniProt :accession Q9UL62