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short transient receptor potential channel 4 (TrpC4, Trp-related protein 4, hTrp-4, hTrp4, TRPC4)
Function:
1) forms a receptor-activated non-selective Ca+2 channel (putative)
2) regulated by phosphatidylinositol 2nd messenger system activated by receptor tyrosine kinases or G-protein coupled receptors
3) may also be activated by intracellular Ca+2 store depletion
4) isoform alpha but not isoform beta associates with inositol-1,4,5-triphosphate receptor (ITPR)
5) interacts with NHERF
Compartment: membrane
Alternative splicing: named isoforms=4
Expression:
- expressed in placenta > heart, pancreas, kidney, brain
- isoform alpha predominant isoform
- isoform beta not found in pancreas, brain
Structure:
- belongs to the transient receptor family, STrpC subfamily
- contains 2 ANK repeats
General
Ca+2 channel
transmembrane 6 protein
Properties
SIZE: MW = 112 kD
entity length = 977 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-329}
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 69-98
ankyrin repeat
NAME: ankyrin repeat
SITE: 141-170
transmembrane domain {330-350}
exoplasmic loop {351-362}
transmembrane domain {363-383}
cytoplasmic loop {384-436}
transmembrane domain {437-457}
exoplasmic loop {458-469}
transmembrane domain {470-490}
cytoplasmic loop {491-511}
transmembrane domain {512-532}
exoplasmic loop {533-599}
transmembrane domain {600-620}
binding site
SITE: 615-977
FOR-BINDING-OF: IP3 receptor-1
inositol 1,4,5-trisphosphate receptor type 2
inositol 1,4,5-trisphosphate receptor type 3
MOTIF: cytoplasmic domain {621-977}
binding site
SITE: 972-974
FOR-BINDING-OF: Na+/H+ exchange regulatory cofactor NHE-RF1
ION-PERMEABILITY: Ca+2
Database Correlations
OMIM 603651
UniProt Q9UBN4
PFAM correlations
References
UniProt :accession Q9UBN4