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Shadow of prion protein (Protein shadoo) (SPRN SHO)
Function:
- prion-like protein that has PrP(C)-like neuroprotective activity
- may act as a modulator for the biological actions of normal & abnormal PrP (putative)
- N-glycosylated (putative)
Structure: belongs to the SPRN family
Compartment: -cell membrane; lipid-anchor, GPI-anchor
Expression:
- mainly expressed in brain
- in brain, it is expressed in hippocampus
Miscellaneous: 'Shadoo' means 'shadow' in Japanese
General
glycoprotein
Properties
SIZE: entity length = 151 aa
MW = 15 kD
MOTIF: signal sequence {1-24}
alanine-rich region {4-93}
MOTIF: alanine residue (SEVERAL)
N-glycosylation site {N111}
glycosyl phosphatidylinositol [GPI] membrane anchor {N126}
Database Correlations
UniProt Q5BIV9
Kegg hsa:5035
References
UniProt :accession Q5BIV9