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SH3 domain-containing guanine exchange factor (SGEF, ARHGEF26)
Function:
- activates RhoG GTPase by promoting the exchange of GDP by GTP
- required for the formation of membrane ruffles during macropinocytosis
- required for the formation of cup-like structures during trans-endothelial migration of leukocytes
- interacts with ICAM1 & RHOG
Structure:
- contains 1 DH (DBL-homology) domain
- contains 1 PH domain
- contains 1 SH3 domain
Compartment: cell projection, ruffle
Alternative splicing: named isoforms=3
Expression: isoform 1 is broadly expressed, with highest levels in liver (at protein level). isoform 2 is sspecifically expressed in prostate & liver
Pathology:
- in case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements & promotes bacterial entry
- isoform 2 is up-regulated by androgens in prostate cancer cells
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: entity length = 871 aa
MW = 97 kD
MOTIF: proline-rich region
SITE: 106-173
MOTIF: proline residue (SEVERAL)
Dbl homology domain {439-623}
PH domain {655-782}
src homology 3 [SH3] domain
SITE: 789-850
Database Correlations
UniProt Q96DR7
PFAM correlations
Kegg hsa:2608
References
UniProt :accession Q96DR7