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SH3 & multiple ankyrin repeat domains protein 2; Shank2; cortactin-binding protein 1; cortBP1; proline-rich synapse-associated protein 1 (SHANK2, CORTBP1, KIAA1022, PROSAP1)

Function: - seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type & metabotropic glutamate receptors, & the actin-based cytoskeleton - may play a role in the structural & functional organization of the dendritic spine & synaptic junction - interacts with CCTN/cortactin SH3 domain, DLGAP1/GKAP & - alpha-latrotoxin receptor 1 - part of a complex with DLG4/PSD-95 & DLGAP1/GKAP - interacts with GRID2, SLC9A3, CFTR & PLCB3 - interacts with DBNL (putative) - interacts with DNM2 - interacts with BAIAP2 Structure: - the PDZ domain is required for interaction with GRID2, PLCB3, CFTR & SLC9A3 (putative) - belongs to the SHANK family - contains 1 PDZ domain (DHR domain) - contains 1 SAM (sterile alpha motif) domain - contains 1 SH3 domain Compartment: - cytoplasm (putative) - cell junction - synapse, postsynaptic cell membrane, postsynaptic density (putative) Alternative splicing: - named isoforms=4 - additional isoforms seem to exist Expression: - isoform 3 is present in epithelial colonic cells (at protein level)

General

glycoprotein phosphoprotein SH3 & multiple anykrin repeat domains (Shank) protein

Properties

SIZE: entity length = 1470 aa MW = 159 kD COMPARTMENT: cytoplasm MOTIF: src homology 3 [SH3] domain SITE: 147-206 PDZ domain NAME: PDZ domain SITE: 247-341 proline-rich region SITE: 509-535 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S581} Thr phosphorylation site {T726} Thr phosphorylation site {T899} SH3-binding site NAME: SH3-binding site SITE: 948-954 Ser phosphorylation site {S1269} Thr glycosylation site {T1288} Ser phosphorylation site {S1330} Ser phosphorylation site {S1334} Thr phosphorylation site {T1336} sterile alpha motif NAME: sterile alpha motif SITE: 1407-1470

Database Correlations

OMIM 603290 UniProt Q9UPX8 PFAM correlations Entrez Gene 22941 Kegg hsa:22941

References

  1. UniProt :accession Q9UPX8
  2. Sheng M. Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review. PMID: 11416187
  3. OMIM :accession 603290