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SFRS2-interacting protein; splicing factor-arginine/serine-rich 2-interacting protein; SC35-interacting protein 1; CTD-associated SR protein 11; splicing regulatory protein 129; SRrp129; renal carcinoma antigen NY-REN-40; serine/arginine-rich splicing factor 2-interacting protein (SFRS2IP, CASP11, SIP1, SCAF11)
Function:
- pre-mRNA alternative splicing by regulating spliceosome assembly
- interacts with SFRS2, U2AF2, SNRP70
Structure: contains 1 RING-type Zn+2 finger
Compartment: nucleus
Expression: widely expressed
General
nuclear protein
phosphoprotein
ring finger protein
Properties
SIZE: entity length = 1463 aa
MW = 165 kD
COMPARTMENT: cell nucleus
MOTIF: RING-finger {41-82}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Ser phosphorylation site {S338}
Ser phosphorylation site {S341}
Ser phosphorylation site {S344}
Ser phosphorylation site {S400}
Ser phosphorylation site {S401}
Ser phosphorylation site {S402}
Ser phosphorylation site {S405}
Thr phosphorylation site {T410}
Ser phosphorylation site {S413}
Ser phosphorylation site {S533}
Ser phosphorylation site {S608}
Ser phosphorylation site {S614}
Ser phosphorylation site {S680}
Ser phosphorylation site {S687}
Ser phosphorylation site {S723}
Ser phosphorylation site {S726}
Thr phosphorylation site {T769}
Ser phosphorylation site {S771}
Ser phosphorylation site {S776}
Ser phosphorylation site {S796}
Ser phosphorylation site {S798}
Ser phosphorylation site {S802}
Thr phosphorylation site {T807}
Ser phosphorylation site {S816}
arginine-rich region {841-985}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S963}
Ser phosphorylation site {S1127}
Ser phosphorylation site {S1169}
proline-rich region
SITE: 1225-1285
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 603668
UniProt Q99590
Pfam PF13639
Entrez Gene 9169
KEGG correlations
References
UniProt :accession Q99590