Search
histone-lysine N-methyltransferase SETDB2; chronic lymphocytic leukemia deletion region gene 8 protein; lysine N-methyltransferase 1F; SET domain bifurcated 2 (SETDB2, C13orf4, CLLD8 KMT1F)
Function:
1) histone methyltransferase
2) methylates Lys-9 of histone H3
Structure:
- belongs to the histone-lysine methyltransferase family
- contains 1 MBD (methyl-CpG-binding) domain
- contains 1 pre-SET domain
- contains 1 SET domain
Compartment: nucleus
Expression:
- ubiquitous
- highest expression in heart, testis, ovary
General
histone N-methyltransferase
zinc finger protein
Properties
SIZE: entity length = 719 aa
MW = 82 kD
COMPARTMENT: cell nucleus
MOTIF: MBD {157-229}
pre-SET domain {291-364}
MOTIF: Zn+2-binding site
SITE: 293-293
Zn+2-binding site
SITE: 295-295
Zn+2-binding site
SITE: 299-299
Zn+2-binding site
SITE: 305-305
Zn+2-binding site
SITE: 307-307
Zn+2-binding site
SITE: 345-345
Zn+2-binding site
SITE: 349-349
Zn+2-binding site
SITE: 351-351
Zn+2-binding site
SITE: 356-356
SET domain {366-698}
Database Correlations
OMIM 607865
UniProt Q96T68
PFAM correlations
Entrez Gene 83852
Kegg hsa:83852
ENZYME 2.1.1.43
References
UniProt :accession Q96T68