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SET domain
130-140-amino acid domain, evolutionarily conserved.
Initially characterized in Drosophila proteins: Su(var)3-9, Enhancer-of-zeste, Trithorax
Found in proteins from yeast, mammals, bacteria, viruses
In yeast & mammals, found in proteins involved in: methylation of lysine-9 in the histone H3 N-terminus also requires adjacent cysteine-rich regions. pre & post SET
Plant proteins containing SET domains lack pre- &/or post SET cysteins & are unable to methylate histones
Largely beta strands, organized as 2 structural domains that form an L shape. The pre-SET domain forms a triangular zinc cluster with 9 Cys coordinating 3 Zn+2.
General
peptide motif
domain
References
Prosite :accession PS00893