SET complex

Structure: - subunits: at least ANP32A, HMGB2, NME1 & APEX1 Compartment: associated with endoplasmic reticulum

Properties

SUBUNITS: set protein COMPARTMENT: cytoplasm cell nucleus endoplasmic reticulum MOTIF: Ser phosphorylation site {S7} Ser phosphorylation site {S30} acidic region {239-290} MOTIF: acidic residue (SEVERAL) Breakpoint {283-284} acidic leucine-rich nuclear phosphoprotein 32 family member A COMPARTMENT: cytoplasm cell nucleus MOTIF: Thr phosphorylation site {T15} Ser phosphorylation site {S17} leucine-rich repeat SITE: 44-63 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 64-86 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 87-111 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 115-138 MOTIF: leucine residue (SEVERAL) Necessary for tumor-suppressive function {150-174} MOTIF: Ser phosphorylation site {S158} E4F1 interaction {165-249} MOTIF: acidic region {168-249} MOTIF: acidic residue (SEVERAL) high mobility group protein B2 COMPARTMENT: cell nucleus MOTIF: HMG box SITE: 9-79 MOTIF: Ser phosphorylation site {S35} HMG box SITE: 95-163 MOTIF: Tyr phosphorylation site {Y155} Tyr phosphorylation site {Y162} acidic region {186-209} MOTIF: acidic residue (SEVERAL) nucleoside diphosphate kinase-A CONFIGURATION: hexamer COMPARTMENT: cytoplasm cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 12-12 ATP-binding site NAME: ATP-binding site SITE: 60-60 ATP-binding site NAME: ATP-binding site SITE: 88-88 ATP-binding site NAME: ATP-binding site SITE: 94-94 ATP-binding site NAME: ATP-binding site SITE: 105-105 ATP-binding site NAME: ATP-binding site SITE: 115-115 histidine residue {H118} redox repair function-1 COMPARTMENT: cell nucleus MOTIF: manganese [Mn]-binding site SITE: 68-68 manganese [Mn]-binding site SITE: 96-96 manganese [Mn]-binding site SITE: 210-210 manganese [Mn]-binding site SITE: 212-212 Tyr phosphorylation site {Y262} manganese [Mn]-binding site SITE: 308-308 histidine residue {H309} manganese [Mn]-binding site SITE: 309-309

References

UniProt :accession O75081

Components

acidic leucine-rich nuclear phosphoprotein 32 family member A; potent heat-stable protein phosphatase 2A inhibitor I1PP2A; acidic nuclear phosphoprotein pp32; leucine-rich acidic nuclear protein; Lanp; HLA-DR-associated protein I; PHAPI; mapmodulin (ANP32A, C15orf1, LANP, MAPM, PHAP1) high mobility group protein B2; high mobility group protein 2; HMG-2 (HMGB2, HMG2) nucleoside diphosphate kinase-A, (NDP kinase A, tumor metastatic process-associated protein, metastasis inhibition factor nm23, nm23-H1, NME1, nm23/H1 nucleoside diphosphate kinase, granzyme A-activated DNase, GAAD) redox repair function-1; DNA-(apurinic or apyrimidinic site) lyase; AP endonuclease-1; APEX nuclease (ref1) set proto-oncogene protein (suppressor of variegation, enhancer of zeste & trithorax, HLA-DR associated protein II, PHAPII, phosphatase 2A inhibitor I2PP2A, I-2PP2A, template-activating factor I, TAF-I, inhibitor of granzyme A-activated DNase, IGAAD, SET)