SET & MYND domain-containing protein 3 (zinc finger MYND domain-containing protein 1, SMYD3, ZMYND1, ZNFN3A1)

Function: 1) histone methyltransferase 2) specifically methylates Lys-4 of histone H3, inducing di- & tri-methylation, but not monomethylation 3) role in transcriptional activation as component of an RNA polymerase complex 4) histone methyltransferase activity stimulated by HSPCA 5) interacts with HSPCA & HELZ, which functions as bridge between SMYD3 & RNA polymerase 2 6) binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences S-adenosyl-L-methionine + histone L-lysine S-adenosyl-L-homocysteine + histone 6-N-methyl-L-lysine Structure: - contains 1 MYND-type zinc finger Compartment: - cytoplasm, nucleus - mainly cytoplasmic when cells are arrested at G0/G1 - accumulates in nucleus at S phase & G2/M Alternative splicing: named isoforms=2 Expression: expressed in skeletal muscle, testis Pathology: - over-expressed in a majority of: a) colorectal carcinoma b) hepatocellular carcinomas

General

DNA-binding protein histone N-methyltransferase SET & MYND domain-containing protein (SMYD)

Properties

SIZE: MW = 49 kD entity length = 428 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Zinc finger NAME: Zinc finger SITE: 49-87 EFFECTOR-BOUND: Zn+2 SET domain {126-246}

Database Correlations

OMIM 608783 UniProt Q9H7B4 PFAM correlations ENZYME 2.1.1.43

References

UniProt :accession Q9H7B4