sestrin-1 (p53-regulated protein PA26, SESN1, PA26, SEST1)

Function: 1) unkonwn 2) potential regulator of cellular growth 3) isoforms T2 & T3 are induced by genotoxic stress (UV, gamma-irradiation, cytotoxic drugs) {p53-dependent}; isoform T1 is not Compartment: nucleus Alternative splicing: named isoforms=3 Expression: widely expressed Pathology: - defects in SESN1 may be involved in heterotaxia

General

nuclear protein sestrin

Properties

SIZE: MW = 57 kD entity length = 492 aa COMPARTMENT: cell nucleus

Database Correlations

OMIM 606103 UniProt Q9Y6P5 Pfam PF04636

References

UniProt :accession Q9Y6P5