Cdc42 effector protein 1; binder of Rho GTPases 5; serum protein MSE55 (CDC42EP1, BORG5, CEP1, MSE55)

Function: - probably involved in organization of the actin cytoskeleton - induces membrane extensions in fibroblasts - interacts with RHOQ & CDC42 (GTP-dependent) Structure: - the CRIB domain mediates interaction with CDC42 - belongs to the BORG/CEP family - contains 1 CRIB domain Compartment: - endomembrane system; peripheral membrane protein - cytoplasm, cytoskeleton Alternative splicing: named isoforms=2 Expression: endothelial & bone marrow stromal cells

General

phosphoprotein plasma protein

Properties

SIZE: entity length = 391 aa MW = 40 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S19} Ser phosphorylation site {S27} CRIB domain {38-52} Ser phosphorylation site {S101} Ser phosphorylation site {S106} Ser phosphorylation site {S113} Ser phosphorylation site {S121} Ser phosphorylation site {S143} Thr phosphorylation site {T145} Ser phosphorylation site {S190} Ser phosphorylation site {S192} Ser phosphorylation site {S195} [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG] {220-275} MOTIF: consensus repeat {220-226} consensus repeat {227-233} consensus repeat {234-240} consensus repeat {241-247} consensus repeat {248-254} consensus repeat {255-261} consensus repeat {262-268} consensus repeat {269-275} Ser phosphorylation site {S350} Ser phosphorylation site {S353}

Database Correlations

OMIM 606084 UniProt Q00587 Pfam PF00786 Entrez Gene 11135 Kegg hsa:11135

References

UniProt :accession Q00587