serum amyloid A1 protein; SAA; contains: amyloid protein A; amyloid fibril protein AA (SAA1)

Function: - major acute phase reactant - apolipoprotein of the HDL complex - precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end Structure: belongs to the SAA family Compartment: secreted Expression: - expressed & secreted into plasma by the liver - expresse upon cytokine stimulation Polymorphism: - at least 5 different SAA1 alleles have been described: SAA1.1 (SAA1alpha), SAA1.2 (SAA1beta), SAA1.3 (SAA1gamma), SAA1.4 (SAA1delta), SAA1.5 (also named SAA1beta but which differs from SAA1.2 Pathology: - reactive, secondary amyloidosis is characterized by extracellular accumulation in various tissues of the SAA protein. these deposits are highly insoluble & resistant to proteolysis; they disrupt tissue structure & compromise function - elevated serum SSA protein levels may be associated with lung cancer Laboratory: - amyloid A component Ag in tissue

General

acute phase protein amyloid glycoprotein

Properties

SIZE: entity length = 122 aa MW = 14 kD COMPARTMENT: plasma MOTIF: signal sequence {1-18}

Database Correlations

OMIM correlations UniProt P0DJI8 Pfam PF00277 LOCUS-LINK correlations KEGG correlations

References

UniProt :accession P0DJI8