SERTA domain-containing protein 1 (transcriptional regulator interacting with the PHD-bromodomain 1, TRIP-Br1, CDK4-binding protein p34SEI1, SEI-1, SERTAD1, SEI1)

Function: - acts at E2F-responsive promoters to integrate signals of PHD- &/or bromodomain-containing transcription factors - stimulates E2F-1/DP-1 transcriptional activity - renders activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16INK4a - interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B & p300/CBP - binds to DP1 - interacts with CDK4 Structure: contains 1 SERTA domain

General

nuclear protein SERTA domain-containing protein (SERTAD)

Properties

SIZE: MW = 25 kD entity length = 236 aa COMPARTMENT: cell nucleus MOTIF: SERTA {38-85}

Database Correlations

UniProt Q9UHV2 Pfam PF06031

References

UniProt :accession Q9UHV2