Serpin-like protein HMSD; minor histocompatibility protein HMSD; minor histocompatibility serpin domain-containing protein (HMSD)

Function: putative serine protease inhibitor (putative) Structure: belongs to the serpin family Compartment: secreted (putative) Alternative splicing: named isoforms=2 - alternative splicing is due 1 intronic SNP Expression: - highly expressed in dendritic cells & primary leukemia cells, especially those of myeloid lineage Polymorphism: - minor histocompatibility antigen ACC-6 (mHA ACC-6) is encoded by HMSD-v which is an allelic variant of HMSD Note: - translation of HMSD-v form generating mHA ACC-6 is in a frame different from that resulting in HMSD non variant form expression

General

glycoprotein secreted protein serine protease inhibitor; serpin

Properties

SIZE: entity length = 139 aa MW = 15 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-20} N-glycosylation site {N50} INHIBITS: serine protease

Database Correlations

UniProt A8MTL9 Pfam PF00079

References

UniProt :accession A8MTL9