serotonin [5HT]-7 receptor; 5-hydroxytryptamine receptor 7; 5-HT-7; 5HT7; 5-HT-X; serotonin receptor 7 (HTR7)

Function: - one of several receptors for 5-hydroxytryptamine (serotonin) - activity is mediated by G proteins that stimulate adenylate cyclase (Gs protein) Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Alternative splicing: named isoforms=3 Expression: - isoform A is the predominant isoform in spleen, caudate & hippocampus - isoform B is expressed at lower levels, & isoform D is a minor isoform

General

glycoprotein serotonin [5HT] receptor G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 479 aa MW = 54 kD COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {1-83} MOTIF: N-glycosylation site {N5} N-glycosylation site {N66} transmembrane domain {84-104} cytoplasmic loop {105-117} transmembrane domain {118-138} exoplasmic loop {139-157} MOTIF: cysteine residue {C155} MODIFICATION: cysteine residue {C231} transmembrane domain {158-178} cytoplasmic loop {179-201} transmembrane domain {202-222} exoplasmic loop {223-236} MOTIF: cysteine residue {C231} MODIFICATION: cysteine residue {C155} transmembrane domain {237-257} cytoplasmic loop {258-325} transmembrane domain {326-346} exoplasmic loop {347-367} transmembrane domain {368-388} cytoplasmic domain {389-479} MOTIF: cysteine residue {C401} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM 182137 UniProt P34969 Pfam PF00001 Entrez Gene 3363 Kegg hsa:3363

References

UniProt :accession P34969