serotonin [5HT]-4 receptor; 5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; serotonin receptor 4 (HTR4)

Function: - one of the several receptors for 5-hydroxytryptamine (serotonin) - activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (Gs proteins) - isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 & SNX27 isoforms 1 & 2 - isoform 5-HT4(E) interacts with INADL, NOS1 & SEC23A - isoform 5-HT4(A) forms a complex containing SLC9A3R1 & EZR (putative) Structure: belongs to the G-protein coupled receptor 1 family Compartment: - cell membrane, endosome - interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 & EZR might target the protein to specialized subcellular regions, such as microvilli Alternative splicing: named isoforms=7 additional isoforms seem to exist Expression: - isoform 5-HT4(A) is expressed in ileum, brain, & atrium, but not in the cardiac ventricle

General

glycoprotein serotonin [5HT] receptor G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 388 aa MW = 44 kD COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {1-19} MOTIF: N-glycosylation site {N7} transmembrane domain {20-40} cytoplasmic loop {41-58} transmembrane domain {59-79} exoplasmic loop {80-93} MOTIF: cysteine residue {C93} MODIFICATION: cysteine residue {C184} transmembrane domain {94-116} cytoplasmic loop {117-137} transmembrane domain {138-158} exoplasmic loop {159-192} MOTIF: cysteine residue {C184} MODIFICATION: cysteine residue {C93} transmembrane domain {193-213} cytoplasmic loop {214-260} transmembrane domain {261-281} exoplasmic loop {282-294} transmembrane domain {295-315} cytoplasmic domain {316-388} MOTIF: cysteine residue {C329} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM 602164 UniProt Q13639 Pfam PF00001 Entrez Gene 3360 Kegg hsa:3360

References

UniProt :accession Q13639