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serotonin [5HT]-3 receptor
Function:
- permeable to Na+, K+
Pathology:
- activation associated with GI side-effects.
Specific
5-hydroxytryptamine receptor 3C (Serotonin receptor 3C, 5- HT3C, HTR3C)
5-hydroxytryptamine receptor 3D (serotonin receptor 3D, 5-HT3D, HTR3D)
5-hydroxytryptamine receptor 3E (serotonin receptor 3E, 5-HT3E, HTR3E)
serotonin [5HT]-3A receptor; 5-hydroxytryptamine receptor 3A; 5-HT3R; 5-HT3A; 5-HT-3; serotonin receptor 3A; serotonin-gated ion channel receptor (HTR3A, 5HT3R, HTR3)
serotonin [5HT]-3B receptor; 5-hydroxytryptamine receptor 3B (5-HT-3B, 5-HT3B, HTR3B)
General
ionotropic receptor
ionotropic receptor subunit
serotonin [5HT] receptor
Properties
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: ligand-binding site
membrane region
cytoplasmic domain {C-TERMINAL}
MOTIF: hydrophobic region
References
- Barnard EA.
Receptor classes and the transmitter-gated ion channels.
Trends Biochem Sci. 1992 Oct;17(10):368-74. Review.
PMID: 1360717