serotonin [5HT]-3B receptor; 5-hydroxytryptamine receptor 3B (5-HT-3B, 5-HT3B, HTR3B)

Function: - one of several different receptors for 5-hydroxytryptamine (serotonin) - ligand-gated ion channel, which when activated causes fast, depolarizing responses - cation-specific, but otherwise relatively nonselective, ion channel - forms a pentaheteromeric complex with HTR3A, homomeric complex being not functional Structure: - belongs to the ligand-gated ionic channel (TC 1.A.9) family - HA-stretch region of HTR3B seems to be confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers Compartment: - cell membrane - presumably retained within the endoplasmic reticulum unless complexed with HTR3A Alternative splicing: named isoforms=2 Expression: - expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus & the amygdala - detected in the kidney & testis as well as in monocytes of the spleen, small & large intestine, uterus, prostate, ovary & placenta

General

glycoprotein serotonin [5HT]-3 receptor transmembrane 4e protein

Properties

SIZE: entity length = 441 aa MW = 50 kD COMPARTMENT: endoplasmic reticulum MOTIF: exoplasmic domain {22-238} MOTIF: signal sequence {1-21} N-glycosylation site {N52} cysteine residue {C155} MODIFICATION: cysteine residue {C169} cysteine residue {C169} MODIFICATION: cysteine residue {C155} transmembrane domain {239-259} cytoplasmic loop {260-268} transmembrane domain {269-286} exoplasmic loop {287-303} MOTIF: N-glycosylation site {N287} transmembrane domain {304-324} cytoplasmic loop {325-414} MOTIF: HA-stretch {381-413} transmembrane domain {415-435} exoplasmic domain {436-441}

Database Correlations

OMIM 604654 UniProt O95264 PFAM correlations

References

UniProt :accession O95264