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serotonin [5HT]-3A receptor; 5-hydroxytryptamine receptor 3A; 5-HT3R; 5-HT3A; 5-HT-3; serotonin receptor 3A; serotonin-gated ion channel receptor (HTR3A, 5HT3R, HTR3)
Function:
- one of the several receptors for 5-hydroxytryptamine (serotonin)
- ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons
- cation-specific, but otherwise relatively nonselective, ion channel
- forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E
- homomeric complexes are functional but exhibit low conductance, decreased agonist & antagonist affinity with modified voltage dependence
- interacts with RIC3
Structure:
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
- the HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers
Compartment:
- cell junction, synapse, postsynaptic cell membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in cerebral cortex, amygdala, hippocampus, & testis
- detected in monocytes of the spleen & tonsil, in small & large intestine, uterus, prostate, ovary & placenta
General
glycoprotein
serotonin [5HT]-3 receptor
transmembrane 4e protein
Properties
SIZE: entity length = 478 aa
MW = 55 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {24-241}
MOTIF: signal sequence {1-23}
N-glycosylation site {N28}
N-glycosylation site {N104}
cysteine residue {C157}
MODIFICATION: cysteine residue {C171}
N-glycosylation site {N170}
cysteine residue {C171}
MODIFICATION: cysteine residue {C157}
N-glycosylation site {N186}
transmembrane domain {242-268}
cytoplasmic loop {269-273}
transmembrane domain {274-292}
exoplasmic loop {293-302}
transmembrane domain {303-321}
cytoplasmic loop {322-455}
MOTIF: HA-stretch {414-450}
transmembrane domain {456-475}
exoplasmic domain {476-478}
Database Correlations
OMIM 182139
UniProt P46098
PFAM correlations
Entrez Gene 3359
Kegg hsa:3359
References
UniProt :accession P46098