serotonin [5HT]-1F receptor; 5-hydroxytryptamine receptor 1F; 5-HT-1F; serotonin receptor 1F (HTR1F, HTR1EL)

Function: - one of the several receptors for 5-hydroxytryptamine (serotonin) - activity is mediated by G proteins that inhibit adenylate cyclase (Gi proteins) Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane

General

glycoprotein serotonin [5HT]-1 receptor

Properties

SIZE: entity length = 366 aa MW = 42 kD COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {1-23} MOTIF: N-glycosylation site {N5} N-glycosylation site {N10} transmembrane domain {24-48} cytoplasmic loop {49-60} transmembrane domain {61-83} exoplasmic loop {84-94} transmembrane domain {95-119} MOTIF: cysteine residue {C96} MODIFICATION: cysteine residue {C172} cytoplasmic loop {120-139} transmembrane domain {140-161} exoplasmic loop {162-178} MOTIF: cysteine residue {C172} MODIFICATION: cysteine residue {C96} transmembrane domain {179-202} cytoplasmic loop {203-291} transmembrane domain {292-314} exoplasmic loop {315-327} transmembrane domain {328-351} cytoplasmic domain {352-366}

Database Correlations

OMIM 182134 UniProt P30939 Pfam PF00001 Entrez Gene 3355 Kegg hsa:3355

References

UniProt :accession P30939