serotonin [5HT]-1E receptor; 5-hydroxytryptamine receptor 1E; 5-HT-1E; 5-HT1E; serotonin receptor 1E; S31 (HTR1E)

Function: - one of the several receptors for 5-hydroxytryptamine (serotonin) - activity of is mediated by G proteins that inhibit adenylate cyclase (Gi proteins) Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane

General

glycoprotein serotonin [5HT]-1 receptor

Properties

SIZE: entity length = 365 aa MW = 42 kD COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {1-22} MOTIF: N-glycosylation site {N2} N-glycosylation site {N5} transmembrane domain {23-47} cytoplasmic loop {48-59} transmembrane domain {60-81} exoplasmic loop {82-96} MOTIF: cysteine residue {C95} MODIFICATION: cysteine residue {C173} transmembrane domain {97-118} cytoplasmic loop {119-138} transmembrane domain {139-159} exoplasmic loop {160-179} MOTIF: cysteine residue {C173} MODIFICATION: cysteine residue {C95} transmembrane domain {180-201} cytoplasmic loop {202-291} transmembrane domain {292-314} exoplasmic loop {315-324} transmembrane domain {325-347} cytoplasmic domain {348-365}

Database Correlations

OMIM 182132 UniProt P28566 Pfam PF00001 Entrez Gene 3354 Kegg hsa:3354

References

UniProt :accession P28566