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5-hydroxytryptamine receptor 1D; 5-HT-1D; 5-HT-1D-alpha; serotonin receptor 1D (HTR1D HTR1DA HTRL)
Function:
- one of the several receptors for 5-hydroxytryptamine (serotonin)
- activity is mediated by G proteins that inhibit adenylate cyclase (Gi proteins)
- presynaptic autoreceptor on presynaptic axon terminal
- interaction with serotonin turns off further release of serotonin
Structure: belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane
- presynaptic axon terminal
General
glycoprotein
serotonin [5HT]-1 receptor
Properties
SIZE: entity length = 377 aa
MW = 42 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-38}
MOTIF: N-glycosylation site {N5}
N-glycosylation site {N17}
N-glycosylation site {N21}
transmembrane domain {39-62}
cytoplasmic loop {63-75}
transmembrane domain {76-98}
exoplasmic loop {99-108}
transmembrane domain {109-134}
MOTIF: cysteine residue {C111}
MODIFICATION: cysteine residue {C188}
cytoplasmic loop {135-154}
transmembrane domain {155-176}
exoplasmic loop {177-194}
MOTIF: cysteine residue {C188}
MODIFICATION: cysteine residue {C111}
transmembrane domain {195-218}
cytoplasmic loop {219-302}
transmembrane domain {303-326}
exoplasmic loop {327-335}
transmembrane domain {336-360}
cytoplasmic domain {361-377}
Database Correlations
OMIM 182133
UniProt P28221
Pfam PF00001
Entrez Gene 3352
Kegg hsa:3352
References
UniProt :accession P28221