serotonin [5HT]-1B receptor; 5-hydroxytryptamine receptor 1B; 5-HT-1D-beta; 5-HT-1B; 5-HT1B; serotonin receptor 1B; serotonin 1D beta receptor; S12 (HTR1B, HTR1DB)

Function: - one of the several receptors for 5-hydroxytryptamine (serotonin) - activity is mediated by G proteins that inhibit adenylate cyclase (Gi proteins) - phosphorylated - desensitization of the receptor may be mediated by its phosphorylation Structure: - belongs to the G-protein coupled receptor 1 family - palmitoylated Compartment: cell membrane

General

glycoprotein phosphoprotein serotonin [5HT]-1 receptor

Properties

SIZE: entity length = 390 aa MW = 44 kD COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {1-49} MOTIF: N-glycosylation site {N24} N-glycosylation site {N32} transmembrane domain {50-73} cytoplasmic loop {74-86} transmembrane domain {87-109} exoplasmic loop {110-119} transmembrane domain {120-145} MOTIF: cysteine residue {C122} MODIFICATION: cysteine residue {C199} cytoplasmic loop {146-165} transmembrane domain {166-187} exoplasmic loop {188-205} MOTIF: cysteine residue {C199} MODIFICATION: cysteine residue {C122} transmembrane domain {206-229} cytoplasmic loop {230-315} transmembrane domain {316-340} exoplasmic loop {341-347} transmembrane domain {348-373} cytoplasmic domain {374-390} MOTIF: cysteine residue {C388} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM 182131 UniProt P28222 Pfam PF00001 Kegg hsa:3351

References

UniProt :accession P28222