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serologically defined colon cancer antigen 1; nuclear export mediator factor NEMF; antigen NY-CO-1 (NEMF SDCCAG1)
Function:
- role in nuclear export
- interacts (via its N-terminus) with XPO1 (putative)
Structure:
- the N-terminal domain contains a nuclear export signal
- the C-terminal domain may interact with cargo proteins
- belongs to the NEMF family
Compartment: nucleus (putative)
Alternative splicing: named isoforms=5
Expression:
- expressed in brain, heart, liver, lung, spleen, & skeletal muscle
- expressed at lower levels in stomach & testis
Pathology:
- inactive in several lung cancer cell lines
- active in normal lung tissue
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 1076 aa
MW = 123 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S417}
Ser phosphorylation site {S692}
Thr phosphorylation site {T703}
Ser phosphorylation site {S704}
Ser phosphorylation site {S705}
Ser phosphorylation site {S747}
Ser phosphorylation site {S748}
Database Correlations
OMIM 608378
UniProt O60524
PFAM correlations
Entrez Gene 9147
Kegg hsa:9147
References
UniProt :accession O60524