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serine/threonine protein phosphatase 6
Function:
- component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation
Structure:
- heterotrimeric complex formed by
a) the catalytic subunit PPP6C
b) a SAPS domain-containing subunit (PP6R)
c) an ankyrin repeat-domain containing regulatory subunit (ANKRD28)
General
multisubunit protein
serine/threonine phosphatase
Properties
STATE: active state
MOTIF: active site
SUBUNITS: serine/threonine protein phosphatase 6 catalytic subunit
COMPARTMENT: cytoplasm
MOTIF: Iron [Fe]-binding site
SITE: 53-53
Iron [Fe]-binding site
SITE: 55-55
Iron [Fe]-binding site
SITE: 81-81
MOTIF: manganese [Mn]-binding site
SITE: 81-81
manganese [Mn]-binding site
SITE: 113-113
histidine residue {H114}
active site
manganese [Mn]-binding site
SITE: 163-163
manganese [Mn]-binding site
SITE: 237-237
STATE: active state
serine/threonine protein phosphatase 6 regulatory ankyrin repeat subunit A
COMPARTMENT: cell nucleus
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 73-102
ankyrin repeat
NAME: ankyrin repeat
SITE: 106-135
MOTIF: Ser phosphorylation site {S117}
ankyrin repeat
NAME: ankyrin repeat
SITE: 139-168
ankyrin repeat
NAME: ankyrin repeat
SITE: 172-201
ankyrin repeat
NAME: ankyrin repeat
SITE: 205-234
ankyrin repeat
NAME: ankyrin repeat
SITE: 238-267
ankyrin repeat
NAME: ankyrin repeat
SITE: 271-300
ankyrin repeat
NAME: ankyrin repeat
SITE: 304-334
ankyrin repeat
NAME: ankyrin repeat
SITE: 338-367
ankyrin repeat
NAME: ankyrin repeat
SITE: 371-400
ankyrin repeat
NAME: ankyrin repeat
SITE: 404-433
ankyrin repeat
NAME: ankyrin repeat
SITE: 437-466
ankyrin repeat
NAME: ankyrin repeat
SITE: 470-499
ankyrin repeat
NAME: ankyrin repeat
SITE: 503-533
ankyrin repeat
NAME: ankyrin repeat
SITE: 537-567
ankyrin repeat
NAME: ankyrin repeat
SITE: 582-611
ankyrin repeat
NAME: ankyrin repeat
SITE: 615-644
ankyrin repeat
NAME: ankyrin repeat
SITE: 649-678
ankyrin repeat
NAME: ankyrin repeat
SITE: 685-714
ankyrin repeat
NAME: ankyrin repeat
SITE: 718-747
ankyrin repeat
NAME: ankyrin repeat
SITE: 751-780
ankyrin repeat
NAME: ankyrin repeat
SITE: 788-817
ankyrin repeat
NAME: ankyrin repeat
SITE: 820-850
ankyrin repeat
NAME: ankyrin repeat
SITE: 855-884
ankyrin repeat
NAME: ankyrin repeat
SITE: 888-918
ankyrin repeat
NAME: ankyrin repeat
SITE: 922-951
ankyrin repeat
NAME: ankyrin repeat
SITE: 958-987
Ser phosphorylation site {S1040}
Ser phosphorylation site {S1044}
Database Correlations
OMIM 300141
Pfam PF00149
References
UniProt :accession O00743
Components
serine/threonine protein phosphatase 6 catalytic subunit; PP6C (PPP6C, PPP6)
serine/threonine protein phosphatase 6 regulatory ankyrin repeat subunit A; PP6-ARS-A; serine/threonine protein phosphatase 6 regulatory subunit ARS-A; ankyrin repeat domain-containing protein 28; phosphatase interactor targeting protein hnRNP K; PITK (ANKRD28 KIAA0379)