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inactive serine/threonine protein kinase VRK3; serine/threonine protein pseudokinase VRK3; vaccinia-related kinase 3 (VRK3)
Function:
- inactive kinase
- suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates & inactivates ERK in the nucleus
- interacts with DUSP3 (putative)
- interacts with RAN
Structure:
- belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family, VRK subfamily
- contains 1 protein kinase domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Note:
- inactive as a kinase due to its inability to bind ATP [2]
Related
vaccinia virus
General
nuclear protein
serine/threonine protein kinase VRK (Vaccinia-related kinase)
Properties
SIZE: entity length = 474 aa
MW = 53 kD
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {49-64}
MOTIF: Ser phosphorylation site {S55}
Ser phosphorylation site {S59}
Ser phosphorylation site {S82}
Ser phosphorylation site {S83}
Ser phosphorylation site {S90}
Ser phosphorylation site {S136}
kinase domain
SITE: 166-457
MOTIF: ATP-binding site
NAME: ATP-binding site
STATE: active state
Database Correlations
UniProt Q8IV63
Pfam PF00069
Entrez Gene 51231
Kegg hsa:51231
References
- UniProt :accession Q8IV63
- Scheeff ED et al
Structure of the pseudokinase VRK3 reveals a degraded catalytic
site, a highly conserved kinase fold, and a putative regulatory
binding site.
Structure. 2009 Jan 14;17(1):128-38.
PMID: 19141289