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serine/threonine protein kinase TNNI3K; TNNI3-interacting kinase; cardiac ankyrin repeat kinase (TNNI3K, CARK)
Function:
- may play a role in cardiac physiology
- autophosphorylated
- interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 & HADHB
Cofactor: Mg+2
Structure:
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
- contains 10 ANK repeats
- contains 1 protein kinase domain
Compartment:
- nucleus, cytoplasm
- expressed at lower levels in the cytoplasm
Alternative splicing: named isoforms=4
Expression:
- highly expressed in both adult & fetal heart
General
nuclear protein
serine/threonine kinase
Properties
SIZE: MW = 104 kD
entity length = 936 aa
COMPARTMENT: cell nucleus
MOTIF: coiled coil {122-152}
ankyrin repeat
NAME: ankyrin repeat
SITE: 167-197
ankyrin repeat
NAME: ankyrin repeat
SITE: 201-230
ankyrin repeat
NAME: ankyrin repeat
SITE: 234-263
ankyrin repeat
NAME: ankyrin repeat
SITE: 267-296
ankyrin repeat
NAME: ankyrin repeat
SITE: 300-329
ankyrin repeat
NAME: ankyrin repeat
SITE: 335-364
ankyrin repeat
NAME: ankyrin repeat
SITE: 370-399
ankyrin repeat
NAME: ankyrin repeat
SITE: 405-436
ankyrin repeat
NAME: ankyrin repeat
SITE: 440-469
ankyrin repeat
NAME: ankyrin repeat
SITE: 482-511
kinase domain
SITE: 564-824
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 570-578
ATP-binding site
NAME: ATP-binding site
SITE: 591-591
aspartate residue {D689}
serine-rich region {834-847}
MOTIF: serine residue (SEVERAL)
STATE: active state
Database Correlations
OMIM 613932
UniProt Q59H18
PFAM correlations
LOCUS-LINK correlations
KEGG correlations
ENZYME 2.7.11.1
References
- UniProt :accession Q59H18
- SeattleSNPs
http://pga.gs.washington.edu/data/tnni3k/