serine/threonine protein kinase PRP4 homolog; PRP4 kinase; PRP4 pre-mRNA-processing factor 4 homolog (PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K)

Function: - role in pre-mRNA splicing - phosphorylates SF2/ASF - phosphorylated by Clk1 - identified in the spliceosome C complex - interacts with Clk1 C-terminus Structure: - belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family - contains 1 protein kinase domain Compartment: nucleus Expression: ubiquitous

General

nuclear protein phosphoprotein serine/threonine kinase

Properties

SIZE: entity length = 1007 aa MW = 117 kD COMPARTMENT: cell nucleus STATE: active state MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Thr phosphorylation site {T6} Ser phosphorylation site {S8} Ser phosphorylation site {S20} Ser phosphorylation site {S23} Ser phosphorylation site {S32} Ser phosphorylation site {S36} lysine-rich region {39-496} MOTIF: lysine residue (SEVERAL) histidine-rich region {40-78} MOTIF: histidine residue (SEVERAL) Ser phosphorylation site {S87} Ser phosphorylation site {S93} Tyr phosphorylation site {Y140} Ser phosphorylation site {S142} Ser phosphorylation site {S144} Ser phosphorylation site {S239} Ser phosphorylation site {S241} Ser phosphorylation site {S257} Ser phosphorylation site {S277} Ser phosphorylation site {S292} Ser phosphorylation site {S294} Ser phosphorylation site {S328} Ser phosphorylation site {S354} Ser phosphorylation site {S356} Ser phosphorylation site {S366} Ser phosphorylation site {S368} Ser phosphorylation site {S381} Thr phosphorylation site {T385} Ser phosphorylation site {S387} Ser phosphorylation site {S410} Ser phosphorylation site {S411} Ser phosphorylation site {S427} Ser phosphorylation site {S431} Ser phosphorylation site {S437} Ser phosphorylation site {S518} Ser phosphorylation site {S519} Ser phosphorylation site {S520} Ser phosphorylation site {S569} Thr phosphorylation site {T576} Ser phosphorylation site {S578} Ser phosphorylation site {S580} kinase domain SITE: 687-1006 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 693-701 ATP-binding site NAME: ATP-binding site SITE: 717-717 aspartate residue {D815} Tyr phosphorylation site {Y849} Ser phosphorylation site {S852}

Database Correlations

OMIM 602338 UniProt Q13523 Pfam PF00069 Entrez Gene 8899 Kegg hsa:8899 ENZYME 2.7.11.1

References

UniProt :accession Q13523