serine/threonine protein kinase Nek4; never in mitosis A-related kinase 4; NimA-related protein kinase 4; serine/threonine protein kinase 2; serine/threonine protein kinase NRK2 (NEK4, STK2)

Function: - serine/threonine protein kinase - seems to act exclusively upon threonine residues (Thr) Structure: - belongs to the protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily - contains 1 protein kinase domain Compartment: nucleus (probable) Alternative splicing: named isoforms=2 Expression: - expression in adult heart > pancreas, skeletal muscle, brain, liver, kidney, lung & placenta - present in most primary carcinomas

General

nuclear protein serine/threonine protein kinase NEK (never in mitosis gene A-related kinase, NimA-related protein kinase, NimA-like protein kinase)

Properties

SIZE: entity length = 841 aa MW = 95 kD COMPARTMENT: cell nucleus MOTIF: kinase domain SITE: 6-261 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 12-20 ATP-binding site NAME: ATP-binding site SITE: 35-35 aspartate residue {D131} Thr phosphorylation site {T165} Ser phosphorylation site {S484} Ser phosphorylation site {S563} STATE: active state

Database Correlations

OMIM 601959 UniProt P51957 Pfam PF00069 Entrez Gene 6787 Kegg hsa:6787 ENZYME 2.7.11.1

References

UniProt :accession P51957