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serine/threonine protein kinase Nek1; never in mitosis A-related kinase 1; NimA-related protein kinase 1; renal carcinoma antigen NY-REN-55 (NEK1, KIAA1901)
Function:
- phosphorylates Ser & Thr
- also appears to possess tyrosine kinase activity
- implicated in control of meiosis (putative)
- role in cilium assembly
- binds to SPERT (putative)
Cofactor: Mg+2
Structure:
- belongs to the protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
- contains 1 protein kinase domain
Compartment:
- nucleus (probable), cytoplasm, cytoskeleton, centrosome (putative)
- associated with the pericentriolar material
- localizes to centrosome during interphase & mitosis (putative)
Alternative splicing: named isoforms=5
Expression: high fetal expression in the brain & kidney
Pathology:
- defects in NEK1 are the cause of short rib-polydactyly syndrome type 2
General
nuclear protein
serine/threonine protein kinase NEK (never in mitosis gene A-related kinase, NimA-related protein kinase, NimA-like protein kinase)
Properties
SIZE: entity length = 1258 aa
MW = 143 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: kinase domain
SITE: 4-258
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 10-18
ATP-binding site
NAME: ATP-binding site
SITE: 33-33
aspartate residue {D128}
Ser phosphorylation site {S155}
Thr phosphorylation site {T162}
Thr phosphorylation site {T344}
Ser phosphorylation site {S414}
Ser phosphorylation site {S418}
Ser phosphorylation site {S428}
Ser phosphorylation site {S653}
Thr phosphorylation site {T661}
Ser phosphorylation site {S664}
Ser phosphorylation site {S798}
Ser phosphorylation site {S806}
Ser phosphorylation site {S834}
Ser phosphorylation site {S837}
Ser phosphorylation site {S868}
Ser phosphorylation site {S881}
Ser phosphorylation site {S1008}
Ser phosphorylation site {S1052}
Tyr phosphorylation site {Y1125}
Ser phosphorylation site {S1126}
STATE: active state
Database Correlations
OMIM correlations
UniProt Q96PY6
Pfam PF00069
Entrez Gene 4750
Kegg hsa:4750
ENZYME 2.7.11.1
References
UniProt :accession Q96PY6