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serine/threonine protein kinase LMTK2 (lemur tyrosine kinase 2, serine/threonine protein kinase KPI-2, kinase/phosphatase/inhibitor 2, apoptosis-associated tyrosine kinase 2, brain-enriched kinase, hBREK, CDK5/p35-regulated kinase, CPRK, LMTK2, AATYK2, BREK, KIAA1079, KPI2, LMR2)
Function:
1) phosphorylates PPP1C, phosphorylase-B & CFTR
2) interacts with PPP1C and inhibitor-2
3) autophosphorylation
Structure:
- belongs to the Tyr protein kinase family.
- contains 1 protein kinase domain
Compartment: membrane
Expression:
- expressed in skeletal muscle > brain, pancreas
General
glycoprotein
membrane protein
serine/threonine kinase
Properties
SIZE: MW = 165 kD
entity length = 1503 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-26}
transmembrane domain {43-63}
N-glycosylation site {N112}
kinase domain
SITE: 137-407
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 143-151
ATP-binding site
NAME: ATP-binding site
SITE: 168-168
aspartate residue {D265}
N-glycosylation site {N352}
N-glycosylation site {N544}
N-glycosylation site {N786}
N-glycosylation site {N881}
N-glycosylation site {N1109}
N-glycosylation site {N1170}
proline-rich region
SITE: 1451-1454
MOTIF: proline residue (SEVERAL)
STATE: active state
Database Correlations
UniProt Q8IWU2
Pfam PF07714
ENZYME 2.7.11.1
References
UniProt :accession Q8IWU2