serine/threonine protein kinase Kist; kinase interacting with stathmin; U2AF homology motif kinase 1 (UHMK1, KIS, KIST)

Function: - upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location & cell cycle progression in G1 phase - may be involved in trafficking &/or processing of RNA (putative) - interacts with stathmin & CDKN1B/p27Kip1 Structure: - belongs to the protein kinase superfamily, Ser/Thr protein kinase family - contains 1 protein kinase domain - contains 1 RRM domain (RNA recognition motif) Compartment: - nucleus - mostly nuclear Alternative splicing: named isoforms=2 Expression: - widely expressed - highest levels in skeletal muscle, kidney, placenta & peripheral blood leukocytes - induced by serum growth factors (putative)

General

nuclear protein RNA-binding protein serine/threonine kinase

Properties

SIZE: entity length = 419 aa MW = 47 kD COMPARTMENT: cell nucleus MOTIF: kinase domain SITE: 23-304 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 29-37 ATP-binding site NAME: ATP-binding site SITE: 54-54 aspartate residue {D158} RNP motif NAME: RNP motif SITE: 324-406 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif STATE: active state

Database Correlations

OMIM 608849 UniProt Q8TAS1 PFAM correlations Entrez Gene 127933 Kegg hsa:127933 ENZYME 2.7.11.1

References

UniProt :accession Q8TAS1