Search
serine/threonine protein kinase haspin; germ cell-specific gene 2 protein; H-haspin; haploid germ cell-specific nuclear protein kinase (GSG2)
Function:
- required for normal alignment of chromosomes at metaphase
- phosphorylates histone H3 Thr-3 during mitosis
- autophosphorylated on both Ser & Thr
- phosphorylated during mitosis
- phosphorylated upon DNA damage, probably by ATM or ATR
Cofactor: Mg+2
Structure:
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family, Haspin subfamily
- contains 1 protein kinase domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- strongly expressed in testis
- also present in thymus & bone marrow
- low levels observed in prostate, intestine, lung, spleen & lymph node
- expressed in fetal skin, liver, kidney & small intestine
- expressed in proliferating cell lines
- not expressed in non-proliferating cell lines
General
nuclear protein
serine/threonine kinase
Properties
SIZE: entity length = 798 aa
MW = 88 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S58}
Ser phosphorylation site {S93}
Thr phosphorylation site {T97}
Ser phosphorylation site {S143}
Ser phosphorylation site {S147}
Ser phosphorylation site {S220}
Thr phosphorylation site {T253}
kinase domain
SITE: 484-798
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 490-498
ATP-binding site
NAME: ATP-binding site
SITE: 511-511
aspartate residue {D649}
STATE: active state
Database Correlations
OMIM 609240
UniProt Q8TF76
PFAM correlations
Entrez Gene 83903
Kegg hsa:83903
ENZYME 2.7.11.1
References
UniProt :accession Q8TF76