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receptor-interacting serine/threonine protein kinase 4; ankyrin repeat domain-containing protein 3; PKC-delta-interacting protein kinase (RIPK4, ANKRD3, DIK)
Function:
- plays a role in NF-kappa B activation
- may be phosphorylated by MAP3K2 & MAP3K3 (putative)
- proteolytically cleaved by during Fas-induced apoptosis
- cleavage at Asp-388 & Asp-426
- interacts with PRKCB (putative)
- interacts with TRAF1, TRAF2, TRAF3 & TRAF5 ,
Structure:
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family
- contains 10 ANK repeats
- contains 1 protein kinase domain
Compartment:
- cytoplasm, membrane
Alternative splicing: named isoforms=2
General
ankyrin repeat domain protein (ANKRD)
receptor-interacting serine/threonine protein kinase (RIPK)
Properties
SIZE: entity length = 832 aa
MW = 92 kD
COMPARTMENT: cytoplasm
MOTIF: kinase domain
SITE: 22-286
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 28-36
ATP-binding site
NAME: ATP-binding site
SITE: 51-51
aspartate residue {D143}
proteolytic site {388-389}
proteolytic site {426-427}
ankyrin repeat
NAME: ankyrin repeat
SITE: 485-514
ankyrin repeat
NAME: ankyrin repeat
SITE: 518-547
ankyrin repeat
NAME: ankyrin repeat
SITE: 551-580
ankyrin repeat
NAME: ankyrin repeat
SITE: 584-613
ankyrin repeat
NAME: ankyrin repeat
SITE: 617-647
ankyrin repeat
NAME: ankyrin repeat
SITE: 651-680
ankyrin repeat
NAME: ankyrin repeat
SITE: 684-713
ankyrin repeat
NAME: ankyrin repeat
SITE: 717-746
ankyrin repeat
NAME: ankyrin repeat
SITE: 750-780
ankyrin repeat
NAME: ankyrin repeat
SITE: 782-811
STATE: active state
Database Correlations
OMIM 605706
UniProt P57078
PFAM correlations
ENZYME 2.7.11.1
References
UniProt :accession P57078