STE20/SPS1-related proline-alanine-rich protein kinase; ste-20-related kinase; DCHT; serine/threonine protein kinase 39 (STK39, SPAK)

Function: - may act as a mediator of stress-activated signals - phosphorylated form forms a complex with WNK2 Structure: - PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins - belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily - contains 1 protein kinase domain Compartment: - cytoplasm, nucleus (probable) - nucleus when caspase-cleaved (probable) Expression: - expressed in brain & pancreas > heart, lung, kidney, skeletal muscle, liver, placenta & testis

General

nuclear protein serine/threonine kinase

Properties

SIZE: entity length = 545 aa MW = 59 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl proline-rich region SITE: 12-53 MOTIF: proline residue (SEVERAL) kinase domain SITE: 63-337 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 69-77 ATP-binding site NAME: ATP-binding site SITE: 92-92 aspartate residue {D192} Thr phosphorylation site {T354} nuclear translocation signal {360-366} Ser phosphorylation site {S370} Ser phosphorylation site {S371} Ser phosphorylation site {S385} Caspase cleavage related site {387-391} STATE: active state

Database Correlations

OMIM 607648 UniProt Q9UEW8 PFAM correlations Entrez Gene 27347 Kegg hsa:27347 ENZYME 2.7.11.1

References

UniProt :accession Q9UEW8