serine/threonine protein kinase 38; NDR1 protein kinase; nuclear Dbf2-related kinase 1 (STK38, NDR1)

Function: - negative regulator of MAP3K1/2 signaling - converts MAP3K2 from its phosphorylated form to its nonphosphorylated form & inhibits autophosphorylation of MAP3K2 - activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP binding & autophosphorylation of Ser-281 - Thr-444 then undergoes Ca⁺²-dependent phosphorylation by STK24/MST3 - interactions between phosphorylated Thr-444 & the N-lobe promote additional structural changes that complete activation - autoinhibition is also released by the binding of MOB1/MOBKL1A & MOB2/HCCA2 to the N-terminal of STK38 - ISGylated (probable) - phosphorylated by STK3/MST2 & this is enhanced by MOBKL1B - homodimeric S100B binds two molecules of STK38 - component of the MLL5-L complex - interacts with MOB1 & MOB2 - interacts with MAP3K1 & MAP3K2 (via kinase domain) - forms a tripartite complex with MOBKL1B & STK3/MST2 Cofactor: Mg⁺² Structure: - belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family - contains 1 AGC-kinase C-terminal domain - contains 1 protein kinase domain Compartment: nucleus. cytoplasm Expression: - ubiquitously expressed - highest expression in peripheral blood leukocytes

General

nuclear protein serine/threonine kinase

Properties

SIZE: entity length = 465 aa MW = 54 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Thr phosphorylation site {T26} S100B interaction {62-87} MOTIF: Thr phosphorylation site {T74} kinase domain SITE: 89-382 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 95-103 ATP-binding site NAME: ATP-binding site SITE: 118-118 aspartate residue {D212} Ser phosphorylation site {S281} AGC-kinase C-terminal {383-455} MOTIF: Thr phosphorylation site {T444} STATE: active state

Database Correlations

OMIM 606964 UniProt Q15208 PFAM correlations Entrez Gene 11329 Kegg hsa:11329 ENZYME 2.7.11.1

References

UniProt :accession Q15208