Search
serine/threonine protein kinase 35; CLP-36-interacting kinase 1; CLIK-1; PDLIM1-interacting kinase 1; serine/threonine protein kinase 35 L1 (STK35, CLIK1, PDIK1, STK35L1)
Function:
- autophosphorylated
- interacts with PDLIM1/CLP-36
Structure:
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family
- contains 1 protein kinase domain
Compartment:
- nucleus, nucleolus. cytoplasm
- when associated with PDLIM1, mostly found in cytoplasm, localized to actin stress fibers [2]
- STK35 only in the nucleus, & the presence of PDLIM1 had no influence on its location [3]
Expression:
- expressed in testis
General
nuclear protein
serine/threonine kinase
Properties
SIZE: entity length = 534 aa
MW = 58 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: alanine-rich region {40-187}
MOTIF: alanine residue (SEVERAL)
kinase domain
SITE: 202-530
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 208-216
ATP-binding site
NAME: ATP-binding site
SITE: 231-231
aspartate residue {D360}
STATE: active state
Database Correlations
OMIM 609370
UniProt Q8TDR2
Pfam PF00069
Entrez Gene 140901
Kegg hsa:140901
ENZYME 2.7.11.1
References
- UniProt :accession Q8TDR2
- Vallenius T and Makela TP.
Clik1: a novel kinase targeted to actin stress fibers by the
CLP-36 PDZ-LIM protein.
J Cell Sci. 2002 May 15;115(Pt 10):2067-73
PMID: 11973348
- Goval P et al
Identifying and characterizing a novel protein kinase STK35L1
and deciphering its orthologs and close-homologs in vertebrates.
PLoS One. 2009 Sep 16;4(9):e6981.
PMID: 19756140