serine/threonine protein kinase 19; protein G11; protein RP1 (STK19, G11, RP1)

Function: - seems to be a protein kinase - in vitro it can phosphorylate casein-alpha on Ser & Thr & histones on Ser - the N-terminus interacts with BAG1 Cofactor: - divalent cations - preference for Mn+2 Structure: belongs to the STK19 family Compartment: nucleus Alternative splicing: named isoforms=4 Expression: - monocytes, hepatocytes, epithelial cells, T-cells, & B-cells

General

nuclear protein serine/threonine kinase

Properties

SIZE: entity length = 368 aa MW = 41 kD COMPARTMENT: cell nucleus MOTIF: S/T phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site STATE: active state

Database Correlations

OMIM 604977 UniProt P49842 Pfam PF10494 Entrez Gene 8859 Kegg hsa:8859 ENZYME 2.7.11.1

References

UniProt :accession P49842