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serine/threonine protein kinase 17B; DAP kinase-related apoptosis-inducing protein kinase 2 (STK17B, DRAK2)
Function:
- acts as a positive regulator of apoptosis
- interacts with CHP causing CHP to translocate from the Golgi to the nucleus (putative)
Structure:
- belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
- contains 1 protein kinase domain
Compartment: nucleus
Expression:
- highly expressed in placenta, lung, pancreas
- lower expression in heart, brain, liver, skeletal muscle & kidney
General
nuclear protein
serine/threonine kinase
Properties
SIZE: entity length = 372 aa
MW = 42 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S10}
kinase domain
SITE: 33-293
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 39-47
ATP-binding site
NAME: ATP-binding site
SITE: 62-62
aspartate residue {D158}
serine-rich region {308-311}
MOTIF: serine residue (SEVERAL)
STATE: active state
Database Correlations
OMIM 604727
UniProt O94768
Pfam PF00069
Entrez Gene 9262
Kegg hsa:9262
ENZYME 2.7.11.1
References
UniProt :accession O94768