Search
probable serine protease HTRA3; high-temperature requirement factor A3; pregnancy-related serine protease (HTRA3 PRSP)
Function:
- probable serine protease
Structure:
- belongs to the peptidase S1B family
- contains 1 IGFBP N-terminal domain
- contains 1 Kazal-like domain
- contains 1 PDZ domain (DHR domain)
Compartment: secreted (putative)
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- highest levels in both adult & fetal heart, ovary, uterus, placenta, & bladder
- isoform 1 is predominant in heart & skeletal muscle
- isoform 2 is predominant in placenta & kidney
General
secreted protein
serine protease
Properties
SIZE: entity length = 453 aa
MW = 49 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-17}
IGFBP N-terminal {21-77}
Kazal-type serine protease inhibitor domain {64-128}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
FOR-BINDING-OF: serine protease
Serine protease {175-340}
MOTIF: histidine residue {H191}
aspartate residue {D227}
serine residue {S305}
PDZ domain
NAME: PDZ domain
SITE: 359-444
Database Correlations
OMIM 608785
UniProt P83110
PFAM correlations
Entrez Gene 94031
Kegg hsa:94031
ENZYME 3.4.21._
References
UniProt :accession P83110