Search
serine protease HTRA1; high-temperature requirement A serine peptidase 1; L56; serine protease 11 (HTRA1, HTRA, PRSS11)
Function:
- serine protease
- may regulate availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins
- represses signaling by TGF-beta family members
Structure:
- belongs to the peptidase S1B family
- contains 1 IGFBP N-terminal domain
- contains 1 Kazal-like domain
- contains 1 PDZ domain (DHR domain)
Compartment: secreted
Expression:
- expressed in a variety of tissues
- strongest expression in placenta
Pathology:
- polymorphism in the promoter region of HTRA1 are the cause of susceptibility to age-related macular degeneration type 7 (ARMD7)
- defects in HTRA1 are the cause of CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts & leukoencephalopathy
General
secreted protein
serine protease
Properties
SIZE: entity length = 480 aa
MW = 51 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
IGFBP N-terminal {33-100}
Kazal-type serine protease inhibitor domain {98-157}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
FOR-BINDING-OF: serine protease
Serine protease {204-364}
MOTIF: histidine residue {H220}
aspartate residue {D250}
serine residue {S328}
PDZ domain
NAME: PDZ domain
SITE: 365-467
Database Correlations
OMIM correlations
MORBIDMAP 602194
UniProt Q92743
PFAM correlations
Entrez Gene 5654
Kegg hsa:5654
References
- UniProt :accession Q92743
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/HTRA1