transmembrane protease serine 11E; serine protease DESC1; transmembrane protease serine 11E2; contains: transmembrane protease serine 11E non-catalytic chain; transmembrane protease serine 11E catalytic chain (TMPRSS11E, DESC1, TMPRSS11E2, UNQ742/PRO1461)

Function: - serine protease - has both gelatinase & caseinolytic activities - preference for Arg in the P1 position (putative) Structure: - N-glycosylated (putative) - belongs to the peptidase S1 family - contains 1 peptidase S1 domain - contains 1 SEA domain Compartment: - cell membrane - single-pass type 2 membrane protein (putative) - transmembrane protease serine 11E catalytic chain - secreted (putative) - activated by cleavage & secreted (putative) Expression: - expression can only be detected in tissues derived from the head & neck, & in skin, prostate & testis Note: - uncertain whether Met-1 or Met-2 is the initiator

General

glycoprotein membrane protein serine protease

Properties

SIZE: entity length = 423 aa MW = 48 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {20-40} SEA domain {44-165} MOTIF: N-glycosylation site {N75} N-glycosylation site {N166} cysteine residue {C177} MODIFICATION: cysteine residue {C-INTERCHAIN} S1 domain {192-422} MOTIF: cysteine residue {C217} MODIFICATION: cysteine residue {C233} N-glycosylation site {N223} histidine residue {H232} cysteine residue {C233} MODIFICATION: cysteine residue {C217} aspartate residue {D277} cysteine residue {C342} MODIFICATION: cysteine residue {C358} cysteine residue {C358} MODIFICATION: cysteine residue {C342} cysteine residue {C369} MODIFICATION: cysteine residue {C398} serine residue {S373} cysteine residue {C398} MODIFICATION: cysteine residue {C369}

Database Correlations

OMIM 610399 UniProt Q9UL52 PFAM correlations Entrez Gene 28983 Kegg hsa:28983

References

UniProt :accession Q9UL52