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serine protease 56 (PRSS56)
Function:
- may play a role in eye development
Structure:
- belongs to the peptidase S1 family
- contains 1 peptidase S1 domain
Expression:
- expressed neural retina, cornea, sclera & optic nerve
Pathology:
- defects in PRSS56 are the cause of microphthalmia isolated type 6
Note:
- product of a dubious gene prediction
General
glycoprotein
serine protease
Properties
SIZE: entity length = 603 aa
MW = 65 kD
MOTIF: signal sequence {1-19}
N-glycosylation site {N97}
S1 domain {105-337}
MOTIF: cysteine residue {C130}
MODIFICATION: cysteine residue {C146}
histidine residue {H145}
cysteine residue {C146}
MODIFICATION: cysteine residue {C130}
aspartate residue {D191}
cysteine residue {C225}
MODIFICATION: cysteine residue {C292}
cysteine residue {C256}
MODIFICATION: cysteine residue {C271}
cysteine residue {C271}
MODIFICATION: cysteine residue {C256}
cysteine residue {C282}
MODIFICATION: cysteine residue {C313}
serine residue {S286}
cysteine residue {C292}
MODIFICATION: cysteine residue {C225}
cysteine residue {C313}
MODIFICATION: cysteine residue {C282}
Database Correlations
OMIM correlations
UniProt P0CW18
Entrez Gene 646960
References
UniProt :accession P0CW18