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serine protease 33 (serine protease EOS, PRSS33)
Function:
- serine protease that has amidolytic activity, cleaving its substrates before Arg residues
Kinetic parameters:
- KM=6.9 mM for H-DL-Val-Leu-Arg-pNA
Structure:
- belongs to the peptidase S1 family
- contains 1 peptidase S1 domain
Compartment: secreted (putative)
Expression:
- predominantly expressed in macrophages
- present in the spleen, small & large intestine, lung & brain (at protein level)
- highly expressed in peripheral leukocytes, ovary, retina, spleen & stomach
- moderately expressed in thymus, uterus & platelets, as well as some brain tissues, including thalamus & fetal brain
- up-regulated by phorbol ester PMA
General
secreted protein
serine protease
Properties
SIZE: entity length = 280 aa
MW = 30 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
active site
MOTIF: serine residue
S1 domain {37-279}
MOTIF: cysteine residue {C62}
MODIFICATION: cysteine residue {C78}
histidine residue {H77}
cysteine residue {C78}
MODIFICATION: cysteine residue {C62}
aspartate residue {D126}
cysteine residue {C160}
MODIFICATION: cysteine residue {C237}
cysteine residue {C193}
MODIFICATION: cysteine residue {C216}
cysteine residue {C216}
MODIFICATION: cysteine residue {C193}
cysteine residue {C227}
MODIFICATION: cysteine residue {C255}
serine residue {S231}
cysteine residue {C237}
MODIFICATION: cysteine residue {C160}
cysteine residue {C255}
MODIFICATION: cysteine residue {C227}
Database Correlations
UniProt Q8NF86
Pfam PF00089
References
UniProt :accession Q8NF86