serine incorporator 5 (SERINC5, C5orf12)

Function: - enhances the incorporation of serine into phosphatidylserine & sphingolipids - may play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (putative) Structure: belongs to the TDE1 family Compartment: endoplasmic reticulum Alternative splicing: named isoforms=3 Expression: - expressed in placenta, skeletal muscle, spleen, thymus, testis & peripheral leukocyte > heart, liver & fetal brain

General

glycoprotein transmembrane 9 protein

Properties

SIZE: entity length = 423 aa MW = 47 kD COMPARTMENT: endoplasmic reticulum MOTIF: exoplasmic domain {1-36} MOTIF: cysteine-rich region {5-26} transmembrane domain {37-57} cytoplasmic loop {58-89} transmembrane domain {90-110} exoplasmic loop {111-124} MOTIF: N-glycosylation site {N113} transmembrane domain {125-145} cytoplasmic loop {146-156} transmembrane domain {157-177} exoplasmic loop {178-198} MOTIF: N-glycosylation site {N183} transmembrane domain {199-219} cytoplasmic loop {220-230} transmembrane domain {231-251} exoplasmic loop {252-258} transmembrane domain {259-279} cytoplasmic loop {280-311} transmembrane domain {312-332} exoplasmic loop {333-385} transmembrane domain {386-406} cytoplasmic domain {407-423}

Database Correlations

UniProt Q86VE9 Pfam PF03348 Kegg hsa:2569

References

UniProt :accession Q86VE9