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serine incorporator 3 (tumor differentially expressed protein 1, SERINC3, DIFF33, TDE1, SBBI99)
Function:
- role in cellular transformation (putative)
Compartment: cell membrane
Expression: ubiquitous
Pathology:
- expression levels increased 4-10 fold in lung tumors compared with normal pulmonary tissue
General
glycoprotein
serine incorporator (SERINC)
transmembrane 8e protein
Properties
SIZE: MW = 53 kD
entity length = 473 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-96}
MOTIF: N-glycosylation site {N34}
transmembrane domain {97-117}
cytoplasmic loop {118-132}
transmembrane domain {133-153}
exoplasmic loop {154-159}
transmembrane domain {160-180}
cytoplasmic loop {181-203}
transmembrane domain {204-224}
exoplasmic loop {225-239}
transmembrane domain {240-260}
cytoplasmic loop {261-329}
transmembrane domain {330-350}
exoplasmic loop {351-406}
transmembrane domain {407-427}
cytoplasmic loop {428-446}
transmembrane domain {447-467}
exoplasmic domain {468-473}
Database Correlations
OMIM 607165
UniProt Q13530
Pfam PF03348
References
UniProt :accession Q13530