serine/arginine repetitive matrix protein 2 (serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kD, Ser/Arg-related nuclear matrix protein, SR-related nuclear matrix protein of 300 kD, splicing coactivator subunit SRm300, 300 kD nuclear matrix antigen, SRRM2, KIAA0324, SRL300, SRM300, HSPC075)

Function: - component of pre- & post-splicing multiprotein mRNP complexes - role in pre-mRNA processing events - binds to RNA - component of active spliceosome - found in a SRRM/SFRS/SNRP pre-mRNA splicing complex - identified in the spliceosome C complex Structure: belongs to the CWC21 family Compartment: nucleus, nuclear speckle Alternative splicing: named isoforms=3 Expression: expressed in liver, placenta, white blood cells

General

nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: MW = 300 kD entity length = 2752 aa COMPARTMENT: cell nucleus MOTIF: coiled coil {60-92} Ser phosphorylation site {S142} serine-rich region {177-2731} MOTIF: serine residue (SEVERAL) lysine-rich region {186-246} MOTIF: lysine residue (SEVERAL) binding site SITE: 197-259 FOR-BINDING-OF: ribonucleic acid Ser phosphorylation site {S250} Thr phosphorylation site {T252} Thr phosphorylation site {T274} Ser phosphorylation site {S297} proline-rich region SITE: 350-447 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S351} Ser phosphorylation site {S353} Thr phosphorylation site {T367} Ser phosphorylation site {S424} arginine-rich region {462-816} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S778} Ser phosphorylation site {S780} Ser phosphorylation site {S783} Ser phosphorylation site {S820} Ser phosphorylation site {S857} Thr phosphorylation site {T866} Ser phosphorylation site {S871} Ser phosphorylation site {S876} Ser phosphorylation site {S901} Thr phosphorylation site {T903} Ser phosphorylation site {S908} Ser phosphorylation site {S914} Ser phosphorylation site {S924} Ser phosphorylation site {S952} Ser phosphorylation site {S954} Ser phosphorylation site {S988} Ser phosphorylation site {S994} Thr phosphorylation site {T1003} Thr phosphorylation site {T1043} Ser phosphorylation site {S1069} Ser phosphorylation site {S1072} Ser phosphorylation site {S1073} Ser phosphorylation site {S1079} Ser phosphorylation site {S1083} Ser phosphorylation site {S1103} Ser phosphorylation site {S1124} Ser phosphorylation site {S1132} Ser phosphorylation site {S1179} Ser phosphorylation site {S1188} Ser phosphorylation site {S1214} Ser phosphorylation site {S1219} Ser phosphorylation site {S1320} Ser phosphorylation site {S1326} Ser phosphorylation site {S1329} Ser phosphorylation site {S1397} Ser phosphorylation site {S1404} Ser phosphorylation site {S1421} Ser phosphorylation site {S1423} Ser phosphorylation site {S1441} Ser phosphorylation site {S1443} Ser phosphorylation site {S1444} Thr phosphorylation site {T1453} Ser phosphorylation site {S1483} Thr phosphorylation site {T1492} Ser phosphorylation site {S1499} Ser phosphorylation site {S1501} Ser phosphorylation site {S1502} Thr phosphorylation site {T1511} Ser phosphorylation site {S1517} Ser phosphorylation site {S1519} Ser phosphorylation site {S1522} Ser phosphorylation site {S1559} Ser phosphorylation site {S1579} Ser phosphorylation site {S1581} Ser phosphorylation site {S1582} Ser phosphorylation site {S1600} Ser phosphorylation site {S1601} Ser phosphorylation site {S1618} Ser phosphorylation site {S1621} arginine-rich region {1666-2089} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S1842} Thr phosphorylation site {T1844} Ser phosphorylation site {S1878} Thr phosphorylation site {T1880} Thr phosphorylation site {T1962} Ser phosphorylation site {S2011} Ser phosphorylation site {S2032} Thr phosphorylation site {T2034} Ser phosphorylation site {S2044} Ser phosphorylation site {S2046} Ser phosphorylation site {S2067} Ser phosphorylation site {S2071} Thr phosphorylation site {T2092} Thr phosphorylation site {T2104} alanine-rich region {2182-2378} MOTIF: alanine residue (SEVERAL) Ser phosphorylation site {S2272} Thr phosphorylation site {T2289} Thr phosphorylation site {T2291} Thr phosphorylation site {T2316} Ser phosphorylation site {S2335} Ser phosphorylation site {S2382} Ser phosphorylation site {S2398} Ser phosphorylation site {S2407} Thr phosphorylation site {T2409} Ser phosphorylation site {S2426} Ser phosphorylation site {S2449} Ser phosphorylation site {S2581} arginine-rich region {2673-2750} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S2692} Ser phosphorylation site {S2694} Ser phosphorylation site {S2714}

Database Correlations

OMIM 606032 UniProt Q9UQ35 Pfam PF08312

References

UniProt :accession Q9UQ35