serine/arginine repetitive matrix protein 1; SR-related nuclear matrix protein of 160 kD; SRm160; Ser/Arg-related nuclear matrix protein (SRRM1 SRM160)

Function: - component of pre- & post-splicing multiprotein mRNP complexes - pre-mRNA processing - promotes constitutive & exonic splicing enhancer-dependent splicing - stimulates mRNA 3'-end cleavage - binds both pre-mRNA & spliced mRNA 20-25 nt upstream of exon-exon junctions - binds RNA & DNA with low sequence specificity - component of the active spliceosome - component of pre-mRNA splicing complex - component of mRNA splicing-dependent exon junction complex - identified in the spliceosome C complex - interacts with BAT1, CPSF1, RBM8A, RNPS1, & THOC4 - seems to be a componnt of RNA export complexes that are released from nuclear speckles (ATP-dependent) Structure: - belongs to the splicing factor SR family - contains 1 PWI domain Compartment: nuclear matrix, nuclear speckle Alternative splicing: named isoforms=2

General

nuclear protein phosphoprotein

Properties

SIZE: MW = 102 kD entity length = 904 aa COMPARTMENT: cell nucleus MOTIF: domain {1-156} MOTIF: binding site SITE: 1-151 FOR-BINDING-OF: deoxyribonucleic acid (DNA) RNA Ser phosphorylation site {S10} PWI {45-118} arginine-rich region {163-726} MOTIF: arginine residue (SEVERAL) proline-rich region SITE: 210-417 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S211} Thr phosphorylation site {T220} serine-rich region {278-756} MOTIF: Ser phosphorylation site (11) {389-549} domain {300-688} proline-rich region SITE: 550-799 MOTIF: proline residue (SEVERAL) Ser phosphorylation site (10) {560-616} Ser phosphorylation site (10) {626-775} Ser phosphorylation site {S781} lysine-rich region {809-835} MOTIF: lysine residue (SEVERAL) alanine-rich region {836-865} MOTIF: alanine residue (SEVERAL)

Database Correlations

OMIM 605975 UniProt Q8IYB3 Pfam PF01480 Entrez Gene 10250 Kegg hsa:10250

References

UniProt :accession Q8IYB3