Search
sentrin-specific protease 6; SUMO-1-specific protease 1; sentrin/SUMO-specific protease SENP6 (SENP6, KIAA0797, SSP1, SUSP1, FKSG6)
Function:
- protease that deconjugates SUMO1, SUMO2 & SUMO3 from targeted proteins
- processes preferentially poly-SUMO2 & poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 & SUMO3 precursors
- deconjugates SUMO1 from RXRA, leading to transcriptional activation
- role in chromosome alignment & spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex
- desumoylates PML & CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation
- also desumoylates RPA1, thus preventing recruitment of RAD51 to the foci of DNA damage
- protein modification; protein sumoylation
- interacts with RXRA
- forms a complex with KAT5-TIP60 & UBE2I in response to UV irradiation
- interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation
Structure:
- belongs to the peptidase C48 family
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- highly expressed in reproductive organs, such as testis, ovary & prostate
Related
small ubiquitin-related modifier 1; SUMO-1; sentrin; ubiquitin-like protein SMT3C; SMT3 homolog 3; ubiquitin-homology domain protein PIC1; ubiquitin-like protein UBL1; GAP-modifying protein 1; GMP1 (SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl43)
General
nuclear protein
phosphoprotein
sentrin-specific protease (SUMO-specific protease)
Properties
SIZE: entity length = 1112 aa
MW = 126 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S6}
Ser phosphorylation site {S9}
Ser phosphorylation site {S335}
Ser phosphorylation site {S336}
Ser phosphorylation site {S350}
Ser phosphorylation site {S352}
Ser phosphorylation site {S361}
Protease {666-1112}
MOTIF: histidine residue {H765}
aspartate residue {D917}
Ser phosphorylation site {S919}
cysteine residue {C1030}
Database Correlations
OMIM 605003
UniProt Q9GZR1
Pfam PF02902
Entrez Gene 26054
Kegg hsa:26054
References
- UniProt :accession Q9GZR1
- OMIM :accession 605003